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Fabrication and characterization of shellac nanofibers with colon-targeted delivery of quercetin and its anticancer activity.
Li, Shu-Fang; Hu, Teng-Gen; Jin, Yuan-Bao; Wu, Hong.
Afiliación
  • Li SF; School of Food Science and Engineering, South China University of Technology, Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety, Guangzhou 510641, China.
  • Hu TG; Sericultural & Agri-Food Research Institute, Guangdong Academy of Agricultural Sciences, Key Laboratory of Functional Foods, Ministry of Agriculture, Guangdong Key Laboratory of Agricultural Products Processing, Guangzhou 510640, China.
  • Jin YB; Ji'an College, Modern Agriculture and Forestry Engineering College, Jian 343000, China. Electronic address: 2009jxncmeet@163.com.
  • Wu H; School of Food Science and Engineering, South China University of Technology, Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety, Guangzhou 510641, China. Electronic address: bbhwu@scut.edu.cn.
Int J Biol Macromol ; 265(Pt 1): 130789, 2024 Apr.
Article en En | MEDLINE | ID: mdl-38479668
ABSTRACT
In this study, the feasibility of shellac nanofibers as carrier system for colonic delivery of quercetin was evaluated. Firstly, the nanofibers without and with different amounts (2.5 %, 5.0 %, and 7.5 %) of quercetin were fabricated using pure shellac as a carrier by electrospinning. The morphology of nanofibers was bead-shape confirmed by SEM. FTIR, XRD, and DSC analysis showed that quercetin was encapsulated into shellac nanofibers, forming an amorphous complex. The molecular docking simulation indicated quercetin bound well to shellac through hydrogen bonding and van der Waals forces. These nanofibers had higher thermal stability than pure quercetin, and their surface wettability exhibited a pH-responsive behavior. The loading capacity of quercetin varied from 2.25 % to 6.84 % with the increased amount of quercetin, and it affected the stability of nanofibers in food simulants by measuring the release profiles of quercetin. The shellac nanofibers had high gastrointestinal stability, with a minimum quercetin release of 16.87 % in simulated digestive fluids, while the remaining quercetin was delivered to the colon and was released gradually. Moreover, the nanofibers exerted enhanced anticancer activity against HCT-116 cells by arresting cell cycle in G0/G1 phase and inducing cell apoptosis. Overall, shellac nanofibers are promising materials for colon-targeted delivery of active compounds.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Quercetina / Resinas de Plantas / Nanofibras Idioma: En Revista: Int J Biol Macromol Año: 2024 Tipo del documento: Article

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Quercetina / Resinas de Plantas / Nanofibras Idioma: En Revista: Int J Biol Macromol Año: 2024 Tipo del documento: Article