Macrophage pyroptosis induced by Candida albicans.
Pathog Dis
; 822024 Feb 07.
Article
en En
| MEDLINE
| ID: mdl-38499444
ABSTRACT
Candida albicans (C. albicans) is a prevalent opportunistic pathogen that causes mucocutaneous and systemic infections, particularly in immunocompromised individuals. Macrophages play a crucial role in eliminating C. albicans in local and bloodstream contexts, while also regulating antifungal immune responses. However, C. albicans can induce macrophage lysis through pyroptosis, a type of regulated cell death. This process can enable C. albicans to escape from immune cells and trigger the release of IL-1ß and IL-18, which can impact both the host and the pathogen. Nevertheless, the mechanisms by which C. albicans triggers pyroptosis in macrophages and the key factors involved in this process remain unclear. In this review, we will explore various factors that may influence or trigger pyroptosis in macrophages induced by C. albicans, such as hypha, ergosterol, cell wall remodeling, and other virulence factors. We will also examine the possible immune response following macrophage pyroptosis.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Candida albicans
/
Candidiasis
/
Piroptosis
/
Macrófagos
Idioma:
En
Revista:
Pathog Dis
Año:
2024
Tipo del documento:
Article