Making Human Hematopoietic Stem Cells Without Transgenes.
Cell Reprogram
; 26(2): 43-45, 2024 Apr.
Article
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| MEDLINE
| ID: mdl-38530081
ABSTRACT
Creating hematopoietic stem cells (HSCs) capable of multilineage engraft while possessing the ability to self-renew stands as a pivotal achievement within the field of regenerative medicine. However, achieving the generation of these cells without transgene expression or teratoma formation has not been fully accomplished. In a recent publication featured in Cell Stem Cell, Piau et al. document the production of functional HSCs derived from human-induced pluripotent stem cells (hiPSCs). They achieved this through a one-step differentiation protocol that notably does not require any transgene expression. hiPSCs-derived HSCs can engraft and self-renew upon serial transplantation and they are able to reconstitute lymphoid, myeloid, and erythroid compartments. This study presents a promising system to further study human HSC ontogeny, and it might represent a crucial step to obtain HSCs.
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Base de datos:
MEDLINE
Asunto principal:
Células Madre Hematopoyéticas
/
Células Madre Pluripotentes Inducidas
Idioma:
En
Revista:
Cell Reprogram
Año:
2024
Tipo del documento:
Article