Antimicrobial activity of eravacycline and other comparative agents on aerobic and anaerobic bacterial pathogens in Taiwan: A clinical microbiological study.
J Glob Antimicrob Resist
; 37: 93-99, 2024 Jun.
Article
en En
| MEDLINE
| ID: mdl-38552878
ABSTRACT
OBJECTIVES:
Eravacycline, a new tetracycline derivative, exhibits broad-spectrum antimicrobial susceptibility. This study aimed to comprehensively investigate in vitro activities of eravacycline, tigecycline, and ertapenem against various Gram-positive, Gram-negative, and anaerobic bacteria.METHODS:
Minimum inhibitory concentrations (MICs) were determined using the broth microdilution method. The following bacterial species were collected vancomycin-sensitive (VS) Enterococci species, vancomycin-resistant Enterococci species (VRE), Staphylococcus aureus, Streptococcus anginosus, Bacteroides species, Clostridioides difficile, Clostridium innocuum, Clostridium perfringens, Parabacteroides distasonis, and Stenotrophomonas maltophilia.RESULTS:
We found that eravacycline exhibited superior in vitro activity compared to tigecycline and ertapenem. Notably, it exhibited the lowest MIC90 for several bacterial species, including VS E. faecalis (0.12 µg/mL), VS E. faecium (0.12 µg/mL), and others. Besides, VRE was susceptible to eravacycline (MIC900.12 µg/mL) and tigecycline (MIC900.12 µg/mL), but was all resistant to ertapenem (MIC90 > 64 µg/mL). S. aureus was also susceptible to eravacycline (MIC900.5 µg/mL) as well as tigecycline (MIC901.0 µg/mL). Furthermore, S. anginosus showed higher susceptibility to eravacycline (MIC902.0 µg/mL) and tigecycline (MIC904.0 µg/mL), but lower to ertapenem (MIC9032.0 µg/mL). Eravacycline and tigecycline also demonstrated good susceptibility to anaerobes, including Bacteroides species (susceptibility rate 100%), P. distasonis (100%), C. difficile (94.1â100%), C. innocuum (94.1â96.1%), and C. perfringens (88.9â96.3%). For S. maltophilia, both tigecycline and eravacycline showed an MIC90 of 2 µg/mL. A moderate-to-strong correlation (rho = 0.608-0.804, P < 0.001) was noted between the MIC values of eravacycline and tigecycline against various bacterial species.CONCLUSIONS:
Our study highlights the potential of eravacycline as an effective treatment option for multidrug-resistant bacterial infections.Palabras clave
Texto completo:
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Base de datos:
MEDLINE
Asunto principal:
Tetraciclinas
/
Bacterias Anaerobias
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Pruebas de Sensibilidad Microbiana
/
Tigeciclina
/
Antibacterianos
País/Región como asunto:
Asia
Idioma:
En
Revista:
J Glob Antimicrob Resist
Año:
2024
Tipo del documento:
Article