Iron-catalyzed selective construction of indole derivatives via oxidative C(sp3)-H functionalization of indolin-2-ones.
Org Biomol Chem
; 22(15): 3073-3079, 2024 Apr 17.
Article
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| MEDLINE
| ID: mdl-38563186
ABSTRACT
Considering the importance of developing powerful catalysts and the pharmacophore characteristics of indole derivatives, we describe a switchable approach for the iron-catalyzed oxidative C(sp3)-H functionalization of indolin-2-ones. Selective transformations displayed excellent activity and chemoselectivity using FeCl2 as the catalyst, air as the oxidant, and alcohol as the solvent. By manipulating the reaction conditions, particularly the choice of solvent, catalyst loading, and reaction sequence, a series of valuable indole derivatives, including isatins and symmetrical and nonsymmetrical isoindigos, were selectively synthesized in good to excellent yields. Furthermore, the gram-scale synthesis of compounds with biological anticancer activity under simple conditions highlights their great potential in practical applications.
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Base de datos:
MEDLINE
Idioma:
En
Revista:
Org Biomol Chem
/
Org. biomol. chem
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Organic & biomolecular chemistry
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2024
Tipo del documento:
Article