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Peripheral helper T cells in human diseases.
Zou, Xueyang; Huo, Feifei; Sun, Lulu; Huang, Jing.
Afiliación
  • Zou X; Department of Clinical Laboratory, The First Hospital of Jilin University, Changchun, 130000, PR China.
  • Huo F; Department of Intensive Care Unit, The First Hospital of Jilin University, Changchun, 130000, PR China.
  • Sun L; Department of Clinical Laboratory, The First Hospital of Jilin University, Changchun, 130000, PR China.
  • Huang J; Department of Clinical Laboratory, The First Hospital of Jilin University, Changchun, 130000, PR China. Electronic address: huangj@jlu.edu.cn.
J Autoimmun ; 145: 103218, 2024 May.
Article en En | MEDLINE | ID: mdl-38574420
ABSTRACT
Peripheral helper T cells (Tph) are a specialized subset of CD4+ T cells with the ability to help B cells and induce antibody production. Although usually located in ectopic lymphoid-like structures (ELS), inside the peripheral blood, Tph cells can also be identified. The aberrant proliferation and functions of Tph cells are commonly found in the patients with disease. In this review, first we will summarize the biological characteristics of Tph cells, such as the expression of surface molecules, transcription factors and cytokines, and discuss its B cell help functions. Tph cells also have roles in a wide range of human diseases, including autoimmune diseases, infectious diseases, malignancies etc. Therefore, there is a strong interest in targeting Tph cells to improve treat strategies of human diseases.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Enfermedades Autoinmunes / Linfocitos T Colaboradores-Inductores Idioma: En Revista: J Autoimmun Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2024 Tipo del documento: Article

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Enfermedades Autoinmunes / Linfocitos T Colaboradores-Inductores Idioma: En Revista: J Autoimmun Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2024 Tipo del documento: Article