Anti-inflammatory Steroids from the South China Sea Sponge Spongia officinalis.
Chem Biodivers
; 21(6): e202400519, 2024 Jun.
Article
en En
| MEDLINE
| ID: mdl-38576052
ABSTRACT
One new highly degraded steroid, namely 21-nor-4-ene-chaxine A (1) furnishing a 5/6/5-tricyclic, along with one known related analogue (2), were isolated from the South China Sea sponge Spongia officinalis. Their structures including absolute configurations were established by extensive spectroscopic data analysis, TDDFT-ECD calculation, and comparison with the spectral data previously reported in the literature. Compound 1 represent the new member of incisterols family with a highly degradation in ring B. In vitro bioassays revealed compound 2 exhibited significant anti-microglial inflammatory effect on lipopolysaccharide (LPS)-induced inflammation in BV-2 microglial cells.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Poríferos
/
Esteroides
/
Lipopolisacáridos
/
Antiinflamatorios
País/Región como asunto:
Asia
Idioma:
En
Revista:
Chem Biodivers
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2024
Tipo del documento:
Article