The helminth-derived peptide, FhHDM-1, reverses the trained phenotype of NOD bone-marrow-derived macrophages and regulates proinflammatory responses.
Eur J Immunol
; 54(6): e2350643, 2024 Jun.
Article
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| MEDLINE
| ID: mdl-38581085
ABSTRACT
We implicate a phenotype of trained immunity in bone-marrow-derived macrophages in the onset and progression of type 1 diabetes in nonobese diabetic mice. Treatment with FhHDM-1 reversed immune training, reducing histone methylation and glycolysis, and decreasing proinflammatory cytokine production to the same level as macrophages from nondiabetic immune-competent BALB/c mice.
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Base de datos:
MEDLINE
Asunto principal:
Ratones Endogámicos NOD
/
Macrófagos
/
Ratones Endogámicos BALB C
Idioma:
En
Revista:
Eur J Immunol
Año:
2024
Tipo del documento:
Article