Vortioxetine-induced syndrome of inappropriate secretion of antidiuretic hormone: A case report.
Neuropsychopharmacol Rep
; 44(2): 479-481, 2024 Jun.
Article
en En
| MEDLINE
| ID: mdl-38588007
ABSTRACT
BACKGROUND:
Vortioxetine, known for its efficacy in treating depression through its effects on various neurotransmitters, has not been previously reported to induce syndrome of inappropriate secretion of antidiuretic hormone (SIADH). CASE PRESENTATION This case report describes a 74-year-old man with major depressive disorder who developed SIADH 1 week after starting treatment with vortioxetine. SIADH is characterized by symptoms such as headache, nausea, disorientation, and seizures, stemming from hyponatremia (123 mEq/L), without dehydration or edema. Vortioxetine was discontinued, and an alternative drug, mianserin, was initiated. The patient was restricted from drinking water due to hyponatremia. The serum Na concentration improved over time to within the normal range by the second week after admission.CONCLUSION:
This is the first case report of vortioxetine-induced SIADH.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Trastorno Depresivo Mayor
/
Vortioxetina
/
Síndrome de Secreción Inadecuada de ADH
Idioma:
En
Revista:
Neuropsychopharmacol Rep
Año:
2024
Tipo del documento:
Article