Central neurocytoma exhibits radial glial cell signatures with FGFR3 hypomethylation and overexpression.
Exp Mol Med
; 56(4): 975-986, 2024 Apr.
Article
en En
| MEDLINE
| ID: mdl-38609519
ABSTRACT
We explored the genomic events underlying central neurocytoma (CN), a rare neoplasm of the central nervous system, via multiomics approaches, including whole-exome sequencing, bulk and single-nuclei RNA sequencing, and methylation sequencing. We identified FGFR3 hypomethylation leading to FGFR3 overexpression as a major event in the ontogeny of CN that affects crucial downstream events, such as aberrant PI3K-AKT activity and neuronal development pathways. Furthermore, we found similarities between CN and radial glial cells based on analyses of gene markers and CN tumor cells and postulate that CN tumorigenesis is due to dysregulation of radial glial cell differentiation into neurons. Our data demonstrate the potential role of FGFR3 as one of the leading drivers of tumorigenesis in CN.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Neurocitoma
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Metilación de ADN
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Receptor Tipo 3 de Factor de Crecimiento de Fibroblastos
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Células Ependimogliales
Idioma:
En
Revista:
Exp Mol Med
Asunto de la revista:
BIOLOGIA MOLECULAR
/
BIOQUIMICA
Año:
2024
Tipo del documento:
Article