In vivo study of porous NiTi cryotweezers for bone tissue cryotherapy.
Cryobiology
; 115: 104894, 2024 Jun.
Article
en En
| MEDLINE
| ID: mdl-38614237
ABSTRACT
This study examined the effects of liquid nitrogen vapor on osteogenesis in the rabbit femur. Cryotweezers made of porous nickel titanium alloy (nitinol or NiTi) obtained by self-propagating high temperature synthesis were used in this experiment. The porous structure of the cryotweezers allows them to hold up to 10 g of liquid nitrogen after being immersed for 2 min, which completely evaporates after 160 s. To study the effects of liquid nitrogen evaporation on osteogenesis, a rabbit femur was perforated. The formed holes were subjected to cryotherapy with varying exposure times. It was found that a 3 s exposure time stimulates osteogenesis, which was manifested in a greater number of osteoblasts in the regenerate compared to the control sample without liquid nitrogen. It was observed that increasing the exposure to 6, 9 or 12 s had a destructive effect, to varying degrees. The most severe damage was exerted by a 12 s exposure, which resulted in the formation of osteonecrosis areas. In the samples exposed to 6 and 9 s of cryotherapy, destruction of the cytoplasm of osteocytes and osteoclasts was observed.
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Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Osteogénesis
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Titanio
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Crioterapia
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Aleaciones
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Fémur
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Níquel
Idioma:
En
Revista:
Cryobiology
Año:
2024
Tipo del documento:
Article