Association of Growth During Infancy with Neurodevelopment and Obesity in Children Born Very Preterm: The Environmental Influences on Child Health Outcomes Cohort.
J Pediatr
; 271: 114050, 2024 Aug.
Article
en En
| MEDLINE
| ID: mdl-38641165
ABSTRACT
OBJECTIVE:
To evaluate associations between change in weight z score after neonatal intensive care unit (NICU) discharge and neurodevelopmental outcomes and obesity at 12-48 months of age among individuals born very preterm. STUDYDESIGN:
This secondary analysis used data from infants born very preterm participating in the Environmental influences on Child Health Outcomes cohort (n = 1400). Growth during infancy was calculated as change in weight z score between NICU discharge and follow-up at a mean of 27 months of age. Very low weight gain was defined as a change in weight z score <-1.67; very high weight gain was a change in weight z score >1.67. Neurodevelopmental outcomes included the Bayley Scales of Infant and Toddler Development, Child Behavior Checklist 1.5-5 years, and Modified Checklist for Autism in Toddlers. Multivariable linear regression was used to estimate associations between increase in weight z score and neurodevelopmental outcomes.RESULTS:
Very low weight gain between NICU discharge and follow-up (experienced by 6.4% of participants) was associated with lower scores on cognitive (adjusted mean difference -4.26; 95% CI -8.55, -0.04) and language (adjusted mean difference -4.80; 95% CI -9.70, -0.11) assessments. Very high weight gain (experienced by 13.6% of participants) was associated with an increased obesity risk (adjusted relative risk 6.20; 95% CI 3.99, 9.66) but not with neurodevelopmental outcomes.CONCLUSIONS:
Very high weight gain in the first 12-48 months after NICU discharge was associated with a higher risk of obesity at follow-up; very low weight gain was associated with lower scores on cognitive and language assessments.Palabras clave
Texto completo:
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Base de datos:
MEDLINE
Asunto principal:
Aumento de Peso
/
Desarrollo Infantil
Idioma:
En
Revista:
J Pediatr
Año:
2024
Tipo del documento:
Article