Comparative evaluation of biomechanical changes and aberration profile following accelerated collagen cross-linking using hypo-osmolar and iso-osmolar riboflavin: A prospective study.
Indian J Ophthalmol
; 72(5): 712-717, 2024 May 01.
Article
en En
| MEDLINE
| ID: mdl-38648433
ABSTRACT
PURPOSE:
To compare the changes encountered in corneal biomechanics and aberration profile following accelerated corneal collagen cross-linking (CXL) using hypo-osmolar and iso-osmolar riboflavin in corneal thicknesses of <400 and >400 microns, respectively.METHODS:
This is a prospective, interventional, comparative study involving 100 eyes of 75 patients with progressive keratoconus. Eyes were divided into two groups based on corneal thickness group 1 included eyes with a corneal thickness of <400 microns who underwent hypo-osmolar CXL, and group 2 included eyes with a corneal thickness of >400 microns who underwent iso-osmolar CXL. Corneal biomechanical and aberration profiles were evaluated and compared between groups.RESULTS:
In group 1, all higher-order aberrations (HOA) except secondary astigmatism significantly decreased from baseline; however, in group 2, only coma and trefoil decreased. The corneal resistance factor and corneal hysteresis significantly improved in both groups, which was significantly greater in group 2 than in group 1. The change in inverse radius, deformation amplitude, and tomographic biomechanical index was significantly improved in group 2 as compared to group 1.CONCLUSION:
Improvement in corrected distance visual acuity and decrease in HOA were significantly better in the hypo-osmolar CXL group; however, the improvement in biomechanical strength of the cornea was significantly better in the iso-osmolar group.
Texto completo:
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Base de datos:
MEDLINE
Asunto principal:
Riboflavina
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Rayos Ultravioleta
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Agudeza Visual
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Colágeno
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Fármacos Fotosensibilizantes
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Córnea
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Topografía de la Córnea
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Reactivos de Enlaces Cruzados
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Queratocono
Idioma:
En
Revista:
Indian J Ophthalmol
Año:
2024
Tipo del documento:
Article