Diagnostic delay of MYH9-related disorder in Japan.
Br J Haematol
; 204(6): 2400-2404, 2024 Jun.
Article
en En
| MEDLINE
| ID: mdl-38650331
ABSTRACT
MYH9-related disorder (MYH9-RD) is characterized by congenital macrothrombocytopenia and granulocyte inclusion bodies. MYH9-RD is often misdiagnosed as chronic immune thrombocytopenia. In this study, we investigated age at definitive diagnosis and indicative thrombocytopenia in 41 patients with MYH9-RD from the congenital thrombocytopenia registry in Japan. Our cohort comprises 54.8% adults over 18 years at confirmed diagnosis. We found a significant difference (p < 0.0001) between the median age at definitive diagnosis of 25.0 years and for indicative thrombocytopenia it was 9.0 years. Our findings strongly suggest diagnostic delay of MYH9-RD in Japan. Our registry system will continue to contribute to this issue.
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Base de datos:
MEDLINE
Asunto principal:
Trombocitopenia
/
Cadenas Pesadas de Miosina
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Diagnóstico Tardío
País/Región como asunto:
Asia
Idioma:
En
Revista:
Br J Haematol
Año:
2024
Tipo del documento:
Article