C-C Bond Cleavage-Induced C- to N-Acyl Transfer for Synthesis of Amides.
Org Lett
; 26(17): 3646-3651, 2024 May 03.
Article
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| MEDLINE
| ID: mdl-38656111
ABSTRACT
A new approach for the preparation of amides was developed using C-C bond cleavage that initiates C- to N-acyl transfer, employing activated ketones as acylation reagents and amine nucleophiles. The reaction was operational under the coupling reagent system that is commonly utilized for peptide bond formations. The method enables practical preparation of amides using linear and cyclic ketone substrates under mild conditions.
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MEDLINE
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En
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Org Lett
Asunto de la revista:
BIOQUIMICA
Año:
2024
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Article