Patient-Derived Xenografts: A Valuable Preclinical Model for Drug Development and Biomarker Discovery.
Methods Mol Biol
; 2806: 19-30, 2024.
Article
en En
| MEDLINE
| ID: mdl-38676793
ABSTRACT
Patient-derived xenografts (PDXs), established by implanting patient tumor cells into immunodeficient mice, offer a platform for faithfully replicating human tumors. They closely mimic the histopathology, genomics, and drug sensitivity of patient tumors. This chapter highlights the versatile applications of PDXs, including studying tumor biology, metastasis, and chemoresistance, as well as their use in biomarker identification, drug screening, and personalized medicine. It also addresses challenges in using PDXs in cancer research, including variations in metastatic potential, lengthy establishment timelines, stromal changes, and limitations in immunocompromised models. Despite these challenges, PDXs remain invaluable tools guiding patient treatment and advancing preclinical drug development.
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Texto completo:
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Base de datos:
MEDLINE
Asunto principal:
Biomarcadores de Tumor
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Ensayos Antitumor por Modelo de Xenoinjerto
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Medicina de Precisión
Idioma:
En
Revista:
Methods Mol Biol
Asunto de la revista:
BIOLOGIA MOLECULAR
Año:
2024
Tipo del documento:
Article