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An international multidisciplinary consensus on pediatric metabolic dysfunction-associated fatty liver disease.
Zhang, Le; El-Shabrawi, Mortada; Baur, Louise A; Byrne, Christopher D; Targher, Giovanni; Kehar, Mohit; Porta, Gilda; Lee, Way Seah; Lefere, Sander; Turan, Serap; Alisi, Anna; Weiss, Ram; Faienza, Maria Felicia; Ashraf, Ambika; Sundaram, Shikha S; Srivastava, Anshu; De Bruyne, Ruth; Kang, Yunkoo; Bacopoulou, Flora; Zhou, Yong-Hai; Darma, Andy; Lupsor-Platon, Monica; Hamaguchi, Masahide; Misra, Anoop; Méndez-Sánchez, Nahum; Ng, Nicholas Beng Hui; Marcus, Claude; Staiano, Amanda E; Waheed, Nadia; Alqahtani, Saleh A; Giannini, Cosimo; Ocama, Ponsiano; Nguyen, Mindie H; Arias-Loste, Maria Teresa; Ahmed, Mohamed Rabea; Sebastiani, Giada; Poovorawan, Yong; Al Mahtab, Mamun; Pericàs, Juan M; Reverbel da Silveira, Themis; Hegyi, Peter; Azaz, Amer; Isa, Hasan M; Lertudomphonwanit, Chatmanee; Farrag, Mona Issa; Nugud, Ahmed Abd Alwahab; Du, Hong-Wei; Qi, Ke-Min; Mouane, Nezha; Cheng, Xin-Ran.
Afiliación
  • Zhang L; Department of Paediatrics, Affiliated Children's Hospital of Jiangnan University (Wuxi Children's Hospital), Wuxi, China.
  • El-Shabrawi M; Department of Pediatrics and Pediatric Hepatology, Faculty of Medicine, Cairo University, Cairo, Egypt.
  • Baur LA; Children's Hospital Westmead Clinical School, Sydney Medical School, The University of Sydney, Sydney, NSW, Australia; Sydney School of Public Health, The University of Sydney, Sydney, NSW, Australia.
  • Byrne CD; Nutrition and Metabolism, Faculty of Medicine, University of Southampton, Southampton, UK; National Institute for Health and Care Research Southampton Biomedical Research Centre, University Hospital Southampton, Southampton, UK.
  • Targher G; Department of Medicine, University of Verona, Verona, Italy; Metabolic Diseases Research Unit, IRCCS Sacro Cuore - Don Calabria Hospital, Negrar di Valpolicella, Italy.
  • Kehar M; Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Eastern Ontario, Department of Pediatrics, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
  • Porta G; Pediatric Hepatology, Transplant Unit, Hospital Sírio-Libanês, Hospital Municipal Infantil Menino Jesus, Sau Paulo, Brazil.
  • Lee WS; Department of Paediatrics, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia.
  • Lefere S; Hepatology Research Unit, Department Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium; Liver Research Center Ghent, Ghent University, Ghent, Belgium.
  • Turan S; Pediatric Endocrinology and Diabetes, Marmara University School of Medicine, Istanbul, Turkey.
  • Alisi A; Research Unit of Molecular Genetics of Complex Phenotypes, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
  • Weiss R; Department of Pediatrics, Ruth Children's Hospital, Rambam Medical Center and the Bruce Rappaport School of Medicine, Technion, Haifa, Israel.
  • Faienza MF; Pediatric Unit, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari "Aldo Moro", Bari, Italy.
  • Ashraf A; Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA.
  • Sundaram SS; Section of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Pediatric Liver Center, Children's Hospital Colorado, University of Colorado School of Medicine and Anschutz Medical Campus, Aurora, CO, USA.
  • Srivastava A; Department of Pediatric Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
  • De Bruyne R; Department of Pediatric Gastroenterology, Hepatology and Nutrition, Ghent University Hospital, Ghent, Belgium.
  • Kang Y; Department of Pediatrics, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea.
  • Bacopoulou F; Center for Adolescent Medicine and UNESCO Chair in Adolescent Health Care, Aghia Sophia Children's Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece; University Research Institute of Maternal and Child Health & Precision Medicine, Medical School, National a
  • Zhou YH; Department of Pediatrics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
  • Darma A; Department of Pediatrics, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
  • Lupsor-Platon M; Department of Medical Imaging, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania; "Prof. Dr. O. Fodor" Regional Institute of Gastroenterology and Hepatology, Cluj-Napoca, Romania.
  • Hamaguchi M; Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.
  • Misra A; Fortis-C-DOC Centre of Excellence for Diabetes, Metabolic Diseases and Endocrinology, New Delhi, India; National Diabetes, Obesity and Cholesterol Foundation (N-DOC), New Delhi, India; Diabetes Foundation, New Delhi, India.
  • Méndez-Sánchez N; Liver Research Unit, Medica Sur Clinic and Foundation and Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico.
  • Ng NBH; Department of Paediatrics, Khoo Teck Puat - National University Children's Medical Institute, National University Hospital, Singapore, Singapore; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
  • Marcus C; Department of Clinical Science, Intervention and Technology, Division of Pediatrics, Karolinska Institutet, Stockholm, Sweden.
  • Staiano AE; Pennington Biomedical Research Center, Baton Rouge, LA, USA.
  • Waheed N; Department of Pediatrics, Shaheed Zulfiqar Ali Bhutto Medical University, Pakistan Institute of Medical Sciences, Islamabad, Pakistan.
  • Alqahtani SA; Organ Transplantation Center of Excellence, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia; Division of Gastroenterology and Hepatology, Johns Hopkins University, Baltimore, MD, USA.
  • Giannini C; Department of Pediatrics, University of Chieti, Chieti, Italy.
  • Ocama P; Department of Internal Medicine, School of Medicine, Makerere University College of Health Sciences, Kampala, Uganda.
  • Nguyen MH; Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University Medical Center, Palo Alto, CA, USA; Department of Epidemiology and Population Health, Stanford University, Stanford, CA, USA.
  • Arias-Loste MT; Hospital Universitario Marqués de Valdecilla, Gastroenterology and Hepatology Department, Clinical and Translational Research in Digestive Diseases, Instituto de Investigación Marqués de Valdecilla (IDIVAL), Santander, Spain.
  • Ahmed MR; Department of Pediatrics, Jahra Hospital, Kuwait and Department of Pediatrics, National Hepatology and Tropical Medicine Research Institute (NHTMRI), Cairo, Egypt.
  • Sebastiani G; Division of Gastroenterology and Hepatology and Division of Infectious Diseases, McGill University Health Centre, Montreal, QC, Canada.
  • Poovorawan Y; Centre of Excellence in Clinical Virology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
  • Al Mahtab M; Department of Hepatology, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka, Bangladesh.
  • Pericàs JM; Liver Unit, Vall d'Hebron University Hospital, Vall d'Hebron Institute for Research (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain; Centros de Investigación Biomédica en Red, Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, Spain.
  • Reverbel da Silveira T; Department of Pediatrics, Faculty of Medicine, Universidade Ciencias da Saude, Porto Alegre, Brazil.
  • Hegyi P; Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary; Center for Translational Medicine, Semmelweis University, Budapest, Hungary; Institute of Pancreatic Diseases, Semmelweis University, Budapest, Hungary.
  • Azaz A; Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates.
  • Isa HM; Pediatric Department, Salmaniya Medical Complex and Pediatric Department, Arabian Gulf University, Manama, Bahrain.
  • Lertudomphonwanit C; Division of Gastroenterology, Department of Paediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
  • Farrag MI; Department of Pediatrics and Pediatric Hepatology, Faculty of Medicine, Cairo University, Cairo, Egypt.
  • Nugud AAA; Department of Pediatrics and Pediatric Hepatology, Faculty of Medicine, Cairo University, Cairo, Egypt.
  • Du HW; Department of Paediatrics, First Hospital of Jilin University, Changchun, China.
  • Qi KM; Laboratory of Nutrition and Development, Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
  • Mouane N; Department of Pediatric Gastroenterology Hepatology and Nutrition, Academic Children's Hospital Ibn Sina, Mohammed V University, Rabat, Morocco.
  • Cheng XR; Department of Paediatric Genetics, Endocrinology and Metabolism, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Med ; 5(7): 797-815.e2, 2024 Jul 12.
Article en En | MEDLINE | ID: mdl-38677287
ABSTRACT

BACKGROUND:

Non-alcoholic fatty liver disease (NAFLD) is highly prevalent in children and adolescents, particularly those with obesity. NAFLD is considered a hepatic manifestation of the metabolic syndrome due to its close associations with abdominal obesity, insulin resistance, and atherogenic dyslipidemia. Experts have proposed an alternative terminology, metabolic dysfunction-associated fatty liver disease (MAFLD), to better reflect its pathophysiology. This study aimed to develop consensus statements and recommendations for pediatric MAFLD through collaboration among international experts.

METHODS:

A group of 65 experts from 35 countries and six continents, including pediatricians, hepatologists, and endocrinologists, participated in a consensus development process. The process encompassed various aspects of pediatric MAFLD, including epidemiology, mechanisms, screening, and management.

FINDINGS:

In round 1, we received 65 surveys from 35 countries and analyzed these results, which informed us that 73.3% of respondents agreed with 20 draft statements while 23.8% agreed somewhat. The mean percentage of agreement or somewhat agreement increased to 80.85% and 15.75%, respectively, in round 2. The final statements covered a wide range of topics related to epidemiology, pathophysiology, and strategies for screening and managing pediatric MAFLD.

CONCLUSIONS:

The consensus statements and recommendations developed by an international expert panel serve to optimize clinical outcomes and improve the quality of life for children and adolescents with MAFLD. These findings emphasize the need for standardized approaches in diagnosing and treating pediatric MAFLD.

FUNDING:

This work was funded by the National Natural Science Foundation of China (82070588, 82370577), the National Key R&D Program of China (2023YFA1800801), National High Level Hospital Clinical Research Funding (2022-PUMCH-C-014), the Wuxi Taihu Talent Plan (DJTD202106), and the Medical Key Discipline Program of Wuxi Health Commission (ZDXK2021007).
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Consenso / Enfermedad del Hígado Graso no Alcohólico Idioma: En Revista: Med / Med (New York. Online) Año: 2024 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Consenso / Enfermedad del Hígado Graso no Alcohólico Idioma: En Revista: Med / Med (New York. Online) Año: 2024 Tipo del documento: Article