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A Review: The Significance of Toll-Like Receptors 2 and 4, and NF-κB Signaling in Endothelial Cells during Atherosclerosis.
Yan, Baoxin; Yu, Xiaoxian; Cai, Xianzhen; Huang, Xiaojun; Xie, Bin; Lian, Danchun; Chen, Jinhao; Li, Weiwen; Lin, Ying; Ye, Junjun; Li, Jilin.
Afiliación
  • Yan B; Department of Cardiology, Second Affiliated Hospital of Shantou University Medical College, 515000 Shantou, Guangdong, China.
  • Yu X; Shantou University Medical College, 515000 Shantou, Guangdong, China.
  • Cai X; Department of Cardiology, Second Affiliated Hospital of Shantou University Medical College, 515000 Shantou, Guangdong, China.
  • Huang X; Department of Cardiology, Second Affiliated Hospital of Shantou University Medical College, 515000 Shantou, Guangdong, China.
  • Xie B; Shantou University Medical College, 515000 Shantou, Guangdong, China.
  • Lian D; Department of Cardiology, Second Affiliated Hospital of Shantou University Medical College, 515000 Shantou, Guangdong, China.
  • Chen J; Department of Cardiology, Second Affiliated Hospital of Shantou University Medical College, 515000 Shantou, Guangdong, China.
  • Li W; Department of Cardiology, Second Affiliated Hospital of Shantou University Medical College, 515000 Shantou, Guangdong, China.
  • Lin Y; Department of Cardiology, Second Affiliated Hospital of Shantou University Medical College, 515000 Shantou, Guangdong, China.
  • Ye J; Shantou University Medical College, 515000 Shantou, Guangdong, China.
  • Li J; Department of Cardiology, Second Affiliated Hospital of Shantou University Medical College, 515000 Shantou, Guangdong, China.
Front Biosci (Landmark Ed) ; 29(4): 161, 2024 Apr 23.
Article en En | MEDLINE | ID: mdl-38682207
ABSTRACT
Atherosclerosis (AS) is a chronic inflammatory vascular disease that begins with endothelial activation followed by a series of inflammatory responses, plaque formation, and finally rupture. An early event in endothelial dysfunction is activation of the nuclear factor-κB (NF-κB) signaling axis. Toll-like receptors (TLRs) in endothelial cells (ECs) play an essential role in recognizing pathogen-associated molecular patterns (PAMPs), damage-associated molecular patterns (DAMPs), and lifestyle-associated molecular patterns (LAMPs). Activation of the canonical NF-κB pathway stimulates the expression of cytokines, chemokines, and an array of additional genes which activate and amplify AS-associated inflammatory responses. In this review, we discuss the involvement of TLR2/4 and NF-κB signaling in ECs during AS initiation, as well as regulation of the inflammatory response during AS by noncoding RNAs, especially microRNA (miRNA) and circular RNA (circRNA).
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Transducción de Señal / FN-kappa B / Células Endoteliales / Aterosclerosis / Receptor Toll-Like 2 / Receptor Toll-Like 4 Idioma: En Revista: Front Biosci (Landmark Ed) Año: 2024 Tipo del documento: Article

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Transducción de Señal / FN-kappa B / Células Endoteliales / Aterosclerosis / Receptor Toll-Like 2 / Receptor Toll-Like 4 Idioma: En Revista: Front Biosci (Landmark Ed) Año: 2024 Tipo del documento: Article