A Review: The Significance of Toll-Like Receptors 2 and 4, and NF-κB Signaling in Endothelial Cells during Atherosclerosis.
Front Biosci (Landmark Ed)
; 29(4): 161, 2024 Apr 23.
Article
en En
| MEDLINE
| ID: mdl-38682207
ABSTRACT
Atherosclerosis (AS) is a chronic inflammatory vascular disease that begins with endothelial activation followed by a series of inflammatory responses, plaque formation, and finally rupture. An early event in endothelial dysfunction is activation of the nuclear factor-κB (NF-κB) signaling axis. Toll-like receptors (TLRs) in endothelial cells (ECs) play an essential role in recognizing pathogen-associated molecular patterns (PAMPs), damage-associated molecular patterns (DAMPs), and lifestyle-associated molecular patterns (LAMPs). Activation of the canonical NF-κB pathway stimulates the expression of cytokines, chemokines, and an array of additional genes which activate and amplify AS-associated inflammatory responses. In this review, we discuss the involvement of TLR2/4 and NF-κB signaling in ECs during AS initiation, as well as regulation of the inflammatory response during AS by noncoding RNAs, especially microRNA (miRNA) and circular RNA (circRNA).
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1
Base de datos:
MEDLINE
Asunto principal:
Transducción de Señal
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FN-kappa B
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Células Endoteliales
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Aterosclerosis
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Receptor Toll-Like 2
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Receptor Toll-Like 4
Idioma:
En
Revista:
Front Biosci (Landmark Ed)
Año:
2024
Tipo del documento:
Article