Herpes zoster vaccination and the risk of dementia: A systematic review and meta-analysis.
Brain Behav
; 14(2): e3415, 2024 Feb.
Article
en En
| MEDLINE
| ID: mdl-38687552
ABSTRACT
INTRODUCTION:
Previous studies have reported a decreased risk of dementia with herpes zoster vaccination. Given this background, this systematic review and meta-analysis aimed to investigate the association between herpes zoster vaccination and the risk of dementia.METHODS:
We searched five databases until November 2023 for case-control, cross-sectional, or cohort studies investigating the association of herpes zoster vaccination and dementia. Odds ratios and 95% confidence intervals (95% CIs) were pooled in the meta-analysis. Meta-regression, subgroup, and sensitivity analysis were also conducted.RESULTS:
We evaluated a total of five studies (one cross-sectional, one case-control, and four cohort studies) that included a total number of 103,615 patients who were vaccinated with herpes zoster vaccine. All the studies were of high quality, ranging from 7 to 9. Due to the high heterogeneity (I2 = 100%, p < .00001) observed in our study, a random effect model was used for the analysis. The pooled odds ratio was 0.84 (95% CI 0.50, 1.43), p (overall effect) = .53), indicating that herpes zoster vaccination reduces the risk of dementia.CONCLUSION:
Herpes zoster vaccination is associated with a reduction of the risk of dementia. More epidemiological studies are needed to confirm the association.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Demencia
/
Vacuna contra el Herpes Zóster
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Herpes Zóster
Idioma:
En
Revista:
Brain Behav
Año:
2024
Tipo del documento:
Article