Modular Approach to Highly Substituted 3-Methylpyridones.
J Org Chem
; 89(10): 7076-7083, 2024 May 17.
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| ID: mdl-38701135
ABSTRACT
A method has been developed for the rapid synthesis of highly substituted 3-methylpyridones via the condensation of Baylis-Hillman amines and ketones under benzoic acid catalysis. The process features readily available starting materials, broad substrate scope, high functional group tolerance, excellent regioselectivity, and gram-scale synthesis. We envision that this on-demand construction of 3-methylpyridones will provide exciting opportunities in biological research, therapeutics, and material sciences.
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MEDLINE
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J Org Chem
Año:
2024
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Article