The molecular basis of phenotypic evolution: beyond the usual suspects.
Trends Genet
; 40(8): 668-680, 2024 Aug.
Article
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| MEDLINE
| ID: mdl-38704304
ABSTRACT
It has been well documented that mutations in coding DNA or cis-regulatory elements underlie natural phenotypic variation in many organisms. However, the development of sophisticated functional tools in recent years in a wide range of traditionally non-model systems have revealed many 'unusual suspects' in the molecular bases of phenotypic evolution, including upstream open reading frames (uORFs), cryptic splice sites, and small RNAs. Furthermore, large-scale genome sequencing, especially long-read sequencing, has identified a cornucopia of structural variation underlying phenotypic divergence and elucidated the composition of supergenes that control complex multi-trait polymorphisms. In this review article we highlight recent studies that demonstrate this great diversity of molecular mechanisms producing adaptive genetic variation and the panoply of evolutionary paths leading to the 'grandeur of life'.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Fenotipo
/
Sistemas de Lectura Abierta
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Evolución Molecular
Idioma:
En
Revista:
Trends Genet
Asunto de la revista:
GENETICA
Año:
2024
Tipo del documento:
Article