Polyhydroxylated Spirostanol Saponins from the Rhizomes of Paris dulongensis.
Chem Biodivers
; 21(7): e202400980, 2024 Jul.
Article
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| MEDLINE
| ID: mdl-38747266
ABSTRACT
Three new polyhydroxylated spirostanol steroidal saponins, dulongenosides B-D (2-4), along with 14 known compounds, dulongenoside A (1), padelaoside B (5), parisyunnanoside G (6), polyphyllin D (7), ophiopogonin C' (8), formosanin C (9), dioscin (10), paris saponin VII (11), paris H (12), parisyunnanoside I (13), protodioscin (14), proprotogracillin (15), crustecdysone (16), and stigmasterol-3-O-ß-d-glucopyranoside (17), were isolated from the rhizomes of Paris dulongensis (Melanthiaceae). Their chemical structures were elucidated based on extensive analyses of NMR and MS data and acidic hydrolyses. The isolates were evaluated for their cytotoxicity to five human cancer cell lines (HL-60, SW480, MDA-MB-231, A549, and A549/Taxol) and the normal human bronchial epithelial cell line BEAS-2B by the MTS test. Compounds 7-12 and 14 showed cytotoxic activity, with IC50 values ranging from 0.20 to 4.35â
µM. Proprotogracillin selectively inhibited A549 (IC50=0.58â
µM) and A549/Taxol (IC50=0.74â
µM) cells, with no significant cytotoxic activity against HL-60, SW480, MDA-MB-231, or BEAS-2B cells, with IC50 values greater than 40â
µM.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Saponinas
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Espirostanos
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Ensayos de Selección de Medicamentos Antitumorales
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Rizoma
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Melanthiaceae
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Antineoplásicos Fitogénicos
Idioma:
En
Revista:
Chem Biodivers
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2024
Tipo del documento:
Article