Association between oxidative balance score and resistant hypertension and arterial stiffness among US adults: A population-based study.
Nutr Metab Cardiovasc Dis
; 34(8): 1901-1911, 2024 Aug.
Article
en En
| MEDLINE
| ID: mdl-38749787
ABSTRACT
BACKGROUND AND AIMS:
Prior studies have established the correlation between oxidative balance score (OBS) and hypertension (HTN). While the association between OBS and resistant hypertension (RHT) as well as arterial stiffness among individuals with hypertension remains undisclosed. METHODS ANDRESULTS:
In this study, total of 15,910 adults diagnosed with hypertension were enrolled from NHANES 2001-2018. OBS was calculated and categorized into quartiles. Weighted regression model, stratified analyses and restricted cubic spline (RCS) were employed to evaluate the association between OBS and RHT, major adverse cardiovascular events (MACEs) and arterial stiffness in individuals with hypertension. Among enrolled participants, high OBS quartiles consistently demonstrated a negative association with resistant hypertension across all models (all p < 0.05), indicating robust stability. Compared with the lowest OBS quartile, the risk of resistant hypertension in the highest OBS quartile was decreased by 30.8% (95%CI 0.471-0.995, p = 0.049). After dividing OBS into dietary OBS and lifestyle OBS, a significant inverse association with lifestyle OBS and RHT was observed. With regard to MACEs, the inverse association was also found in participants with high OBS. Besides, the potential relation between OBS and arterial stiffness was explored and we found OBS was significantly associated with decreased arterial stiffness (ß for ePWV, -0.014; 95%CI -0.026 to -0.001; p = 0.032). RCS analysis confirmed a nonlinear association between OBS and RHT, MACEs, cardiovascular death and nonfatal MI among participants with hypertension.CONCLUSION:
Elevated OBS was negatively associated with the risk of RHT and arterial stiffness among US adults with hypertension.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Presión Sanguínea
/
Resistencia a Medicamentos
/
Encuestas Nutricionales
/
Estrés Oxidativo
/
Rigidez Vascular
/
Hipertensión
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Nutr Metab Cardiovasc Dis
Asunto de la revista:
ANGIOLOGIA
/
CARDIOLOGIA
/
CIENCIAS DA NUTRICAO
/
METABOLISMO
Año:
2024
Tipo del documento:
Article