Infection as a trigger of acute, transient glomerular deposition of clonal immunoglobulins.
Ultrastruct Pathol
; 48(4): 304-309, 2024 Jul 03.
Article
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| MEDLINE
| ID: mdl-38752567
ABSTRACT
Glomerular deposition of monoclonal IgM, frequently in the form of intracapillary pseudothrombi, can be seen in Waldenström macroglobulinemia (WM) and type I cryoglobulinemia (CG). They are typically associated with plasma cell or B-lymphoid neoplasms, particularly lymphoplasmacytic lymphoma (LPL). While infection is a frequent trigger of mixed (type II and III) CG, its association with type I CG is uncommon. We report two cases in which striking lambda-chain-restricted IgM deposits and acute kidney injury (AKI) occurred in the setting of known or suspected systemic infections, with prompt resolution on treatment of the infection.
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Base de datos:
MEDLINE
Asunto principal:
Inmunoglobulina M
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Lesión Renal Aguda
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Glomérulos Renales
Idioma:
En
Revista:
Ultrastruct Pathol
Año:
2024
Tipo del documento:
Article