Metabuli: sensitive and specific metagenomic classification via joint analysis of amino acid and DNA.
Nat Methods
; 21(6): 971-973, 2024 Jun.
Article
en En
| MEDLINE
| ID: mdl-38769467
ABSTRACT
Metagenomic taxonomic classifiers analyze either DNA or amino acid (AA) sequences. Metabuli ( https//metabuli.steineggerlab.com ), however, jointly analyzes both DNA and AA to leverage AA conservation for sensitive homology detection and DNA mutations for specific differentiation of closely related taxa. In the Critical Assessment of Metagenome Interpretation 2 plant-associated dataset, Metabuli covered 99% and 98% of classifications of state-of-the-art DNA- and AA-based classifiers, respectively.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Metagenoma
/
Metagenómica
/
Aminoácidos
Idioma:
En
Revista:
Nat Methods
Asunto de la revista:
TECNICAS E PROCEDIMENTOS DE LABORATORIO
Año:
2024
Tipo del documento:
Article