Development of interpenetrating network hydrogels: Enhancing the release and bioaccessibility of green tea polyphenols.
Int J Biol Macromol
; 271(Pt 2): 132511, 2024 Jun.
Article
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| MEDLINE
| ID: mdl-38772471
ABSTRACT
Green Tea polyphenols (GTP) are important bioactive compounds with excellent physiological regulation functions. However, they are easily destroyed by the gastric environment during digestion. In this work, a sodium alginate (SA)-gellan gum (GG) interpenetrating network (IPN) hydrogel was synthesized to protect and delivery GTP. The ratio of SA/GG significantly affects the network structure of IPN hydrogels and the performance of delivering GTP. The hydrogel formed by interpenetrating 20â¯% GG with 80â¯% SA as the main network had the highest water uptake (55â¯g/g), holding capacity (950â¯mg/g), and freeze-thaw stability, with springiness reaching 0.933 and hardness reaching 1300â¯g, which due to the filling effect and non-covalent interaction. Rheological tests showed that the crosslink density of IPN hydrogel in SA-dominated network was improved by the addition of GG to make it better bound to GTP, and the higher water uptake meant that the system could absorb more GTP-containing solution. This IPN hydrogel maintained 917.3â¯mg/g encapsulation efficiency at the highest loading capacity (1080â¯mg/g) in tests as delivery system. In in vitro digestion simulations, owing to the pH responsiveness, the IPN hydrogel reduced the loss of GTP in gastric fluid, achieving a bioaccessibility of 71.6â¯% in the intestinal tract.
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Base de datos:
MEDLINE
Asunto principal:
Té
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Disponibilidad Biológica
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Hidrogeles
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Polifenoles
Idioma:
En
Revista:
Int J Biol Macromol
Año:
2024
Tipo del documento:
Article