Does brain-derived neurotrophic factor play a role in the association between maternal prenatal mental health and neurodevelopment in 2-year-old children?
J Affect Disord
; 359: 171-179, 2024 Aug 15.
Article
en En
| MEDLINE
| ID: mdl-38777264
ABSTRACT
OBJECTIVE:
To evaluate the role of brain-derived neurotrophic factor (BDNF)-a crucial modulator of neural development and plasticity-in the association between prenatal maternal anxiety, depression, and perceived stress and child neurodevelopment in a prospective cohort study.METHODS:
We included 526 eligible mother-child pairs from the Shanghai Birth Cohort in the study. Maternal mental health was assessed at mid-pregnancy using Zung's Self-Rating Anxiety Scale, Center for Epidemiologic Studies Depression Scale, and Perceived Stress Scale. The concentration of BDNF in cord blood was measured by ELISA. The offspring neurodevelopment at 24 months of age was assessed using the Bayley Scales. Linear and non-linear regression models were used.RESULTS:
The average cord blood BDNF levels were higher in female newborns and those born via vaginal delivery, full term, and normal birth weight. Prenatal maternal anxiety (ß = -0.32; 95 % CI -0.55, -0.09), depression (ß = -0.30; 95 % CI -0.52, -0.08), and perceived stress (ß = -0.41; 95 % CI -0.71, -0.12) scores were negatively associated with social-emotional performance at 24 months of age. However, no significant associations were found between prenatal maternal anxiety, depression, or perceived stress at mid-pregnancy and cord blood BDNF levels, as well as between cord blood BDNF levels and child neurodevelopment.LIMITATIONS:
Maternal mental health at different timepoints during pregnancy and generalizability of the results warrant further assessment.CONCLUSIONS:
Prenatal mental health was not associated with cord blood BDNF level and that BDNF may not be a mediator in the association between prenatal mental health and child neurodevelopment.Palabras clave
Texto completo:
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Base de datos:
MEDLINE
Asunto principal:
Ansiedad
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Efectos Tardíos de la Exposición Prenatal
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Estrés Psicológico
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Desarrollo Infantil
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Factor Neurotrófico Derivado del Encéfalo
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Depresión
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Sangre Fetal
País/Región como asunto:
Asia
Idioma:
En
Revista:
J Affect Disord
Año:
2024
Tipo del documento:
Article