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Relationships between Interleukin 18 -607 C/A and -137 G/C, Osteopontin -9250 C/T Genetic Polymorphisms and Systemic Inflammatory Response Syndrome in Coronary Artery Bypass Graft Surgery.
Köse, Serdal Kenan; Karahilal, Bensu; Engin, Basak; Aydogdu, Gülçin; Yagar, Seyhan; Orhan, Kaan.
Afiliación
  • Köse SK; Department of Biostatistics, Faculty of Medicine, Ankara University, 06620 Ankara, Turkey.
  • Karahilal B; Department of Pharmaceutical Toxicology, Gazi University Faculty of Pharmacy, 06330 Ankara, Turkey.
  • Engin B; Department of Pharmaceutical Toxicology, Gazi University Faculty of Pharmacy, 06330 Ankara, Turkey.
  • Aydogdu G; Department of Biostatistics, Faculty of Medicine, Hitit University, 19030 Çorum, Turkey.
  • Yagar S; Department of Anesthesiology, Ankara City Hospital, 06800 Ankara, Turkey.
  • Orhan K; Department of Dentomaxillofacial Radiology, Faculty of Dentistry, Ankara University, 06620 Ankara, Turkey.
Medicina (Kaunas) ; 60(5)2024 Apr 27.
Article en En | MEDLINE | ID: mdl-38792907
ABSTRACT
Background and

Objectives:

Systemic inflammatory response syndrome (SIRS) is one of the most significant complications after on-pump heart surgery procedures. High cytokine levels have been shown after open-heart surgeries and a genetic predisposition seems to be an important underlying modulatory characteristic for SIRS. To investigate the association between interleukin 18 -607 C/A, interleukin 18 -137 G/C and osteopontin 9250 C/T genetic polymorphisms and SIRS in on-pump CABG patients. Materials and

Methods:

Two hundred consecutive elective on-pump CABG patients were recruited prospectively to the study. Genomic DNA was extracted from whole blood and genotyping was determined by sequence specific PCR or PCR-RFLP methods for related polymorphisms.

Results:

SIRS incidence was 60.2%, 38.1%, 18.9% on postoperative day 1, 2 and 3, respectively, in the whole study population. The SIRS rate on the second postoperative day was 13% and 43.4%, respectively, in osteopontin 9250 C/T T allele non-carriers and carriers (p = 0.004). WBC (White Blood Cell) counts were higher on day 2 and 3 in osteopontin 9250 C/T T allele carriers compared to non-carriers (day 2; 12.7 ± 4 vs. 10.5 ± 2.4 (p = 0.015), day 3; 11.8 ± 4 vs. 9.1 ± 4.7 (p = 0.035)). The average ICU stay was 3.1 ± 7.4, 1.28 ± 0.97 for IL 18-137 G/C C allele carriers and non-carriers, respectively (p = 0.003), and in the IL 18-137 G/C C allele carriers, SIRS developed in 42.2% by the second postoperative day whereas the rate was 57.8% in non-carriers (p = 0.025).

Conclusions:

The current research revealed a possible link between osteopontin 9250 C/T and IL18-137 G/C genetic polymorphism and SIRS and morbidity in on-pump CABG patients.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Puente de Arteria Coronaria / Síndrome de Respuesta Inflamatoria Sistémica / Interleucina-18 / Osteopontina Idioma: En Revista: Medicina (Kaunas) Asunto de la revista: MEDICINA Año: 2024 Tipo del documento: Article

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Puente de Arteria Coronaria / Síndrome de Respuesta Inflamatoria Sistémica / Interleucina-18 / Osteopontina Idioma: En Revista: Medicina (Kaunas) Asunto de la revista: MEDICINA Año: 2024 Tipo del documento: Article