The emerging role of adaptor proteins in regulating innate immunity of sepsis.
Pharmacol Res
; 205: 107223, 2024 Jul.
Article
en En
| MEDLINE
| ID: mdl-38797359
ABSTRACT
Sepsis is a life-threatening syndrome caused by a dysregulated immune response. A large number of adaptor proteins have been found to play a pivotal role in sepsis via protein-protein interactions, thus participating in inflammatory cascades, leading to the generation of numerous inflammatory cytokines, as well as oxidative stress and regulated cell death. Although available strategies for the diagnosis and management of sepsis have improved, effective and specific treatments are lacking. This review focuses on the emerging role of adaptor proteins in regulating the innate immunity of sepsis and evaluates the potential value of adaptor protein-associated therapeutic strategy for sepsis.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Sepsis
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Proteínas Adaptadoras Transductoras de Señales
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Inmunidad Innata
Idioma:
En
Revista:
Pharmacol Res
/
Pharmacol. res
/
Pharmacological Research
Asunto de la revista:
FARMACOLOGIA
Año:
2024
Tipo del documento:
Article