Hand in hand to successful immunotherapy: CD8+ T cells and M1-like macrophages swap the baton.

ABSTRACT

Cancer immunotherapy is a pillar of clinical oncology but only achieves long-term remissions in a minority of cases. In this issue, van Elsas et al. show that effective immunotherapy requires a series of processes orchestrated by CD8+ T cells that result in the recruitment and local activation of M1-like macrophages.