Non-voltage-gated Ca2+ channel signaling in glomerular cells in kidney health and disease.
Am J Physiol Renal Physiol
; 327(2): F249-F264, 2024 Aug 01.
Article
en En
| MEDLINE
| ID: mdl-38867675
ABSTRACT
Positioned at the head of the nephron, the renal corpuscle generates a plasma ultrafiltrate to initiate urine formation. Three major cell types within the renal corpuscle, the glomerular mesangial cells, podocytes, and glomerular capillary endothelial cells, communicate via endocrine- and paracrine-signaling mechanisms to maintain the structure and function of the glomerular capillary network and filtration barrier. Ca2+ signaling mediated by several distinct plasma membrane Ca2+ channels impacts the functions of all three cell types. The past two decades have witnessed pivotal advances in understanding of non-voltage-gated Ca2+ channel function and regulation in the renal corpuscle in health and renal disease. This review summarizes the current knowledge of the physiological and pathological impact of non-voltage-gated Ca2+ channel signaling in mesangial cells, podocytes and glomerular capillary endothelium. The main focus is on transient receptor potential and store-operated Ca2+ channels, but ionotropic N-methyl-d-aspartate receptors and purinergic receptors also are discussed. This update of Ca2+ channel functions and their cellular signaling cascades in the renal corpuscle is intended to inform the development of therapeutic strategies targeting these channels to treat kidney diseases, particularly diabetic nephropathy.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Señalización del Calcio
/
Enfermedades Renales
Idioma:
En
Revista:
Am J Physiol Renal Physiol
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Am. j. physiol., Renal fluid electrolyte physiol
/
American journal of physiology. Renal, fluid and electrolyte physiology
Asunto de la revista:
FISIOLOGIA
/
NEFROLOGIA
Año:
2024
Tipo del documento:
Article