Relationship between human oral microbiome dysbiosis and neuropsychiatric diseases: An updated overview.
Behav Brain Res
; 471: 115111, 2024 Aug 05.
Article
en En
| MEDLINE
| ID: mdl-38871130
ABSTRACT
The role of the gut-brain axis in mental health disorders has been extensively studied. As the oral cavity is the starting point of the digestive tract, the role that the oral microbiota plays in mental health disorders has gained recent attention. Oral microbiota can enter the bloodstream and trigger inflammatory responses or translocate to the brain through the trigeminal nerve or olfactory system. Hence, the concept of the oral microbiota-brain axis has emerged. Several hypotheses have been suggested that the oral microbiota can enter the gastrointestinal tract and affect the gut-brain axis; however, literature describing oral-brain communication remains limited. This review summarizes the characteristics of oral microbiota and its mechanisms associated with mental health disorders. Through a comprehensive examination of the relationship between oral microbiota and various neuropsychiatric diseases, such as anxiety, depression, schizophrenia, autism spectrum disorder, epilepsy, Parkinson's disease, and dementia, this review seeks to identify promising avenues of future research.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Disbiosis
/
Eje Cerebro-Intestino
/
Trastornos Mentales
/
Boca
Idioma:
En
Revista:
Behav Brain Res
Año:
2024
Tipo del documento:
Article