Fear learning induces synaptic potentiation between engram neurons in the rat lateral amygdala.
Nat Neurosci
; 27(7): 1309-1317, 2024 Jul.
Article
en En
| MEDLINE
| ID: mdl-38871992
ABSTRACT
The lateral amygdala (LA) encodes fear memories by potentiating sensory inputs associated with threats and, in the process, recruits 10-30% of its neurons per fear memory engram. However, how the local network within the LA processes this information and whether it also plays a role in storing it are still largely unknown. Here, using ex vivo 12-patch-clamp and in vivo 32-electrode electrophysiological recordings in the LA of fear-conditioned rats, in combination with activity-dependent fluorescent and optogenetic tagging and recall, we identified a sparsely connected network between principal LA neurons that is organized in clusters. Fear conditioning specifically causes potentiation of synaptic connections between learning-recruited neurons. These findings of synaptic plasticity in an autoassociative excitatory network of the LA may suggest a basic principle through which a small number of pyramidal neurons could encode a large number of memories.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Miedo
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Complejo Nuclear Basolateral
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Plasticidad Neuronal
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Neuronas
Idioma:
En
Revista:
Nat Neurosci
Asunto de la revista:
NEUROLOGIA
Año:
2024
Tipo del documento:
Article