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Deferoxamine Intradermal Delivery Patch for Treatment of a Beta-Thalassemia Wound.
Perrault, David; Chattopadhyay, Arhana; Sivaraj, Dharshan; Wan, Derrick; Chen, Kellen; Gurtner, Geoffrey; Sen, Subhro.
Afiliación
  • Perrault D; From the Division of Plastic and Reconstructive Medicine, Stanford University School of Medicine, Stanford University, Stanford, CA.
  • Chattopadhyay A; From the Division of Plastic and Reconstructive Medicine, Stanford University School of Medicine, Stanford University, Stanford, CA.
  • Sivaraj D; From the Division of Plastic and Reconstructive Medicine, Stanford University School of Medicine, Stanford University, Stanford, CA.
  • Wan D; Department of Surgery, the University of Arizona College of Medicine, Tucson, AZ.
  • Chen K; From the Division of Plastic and Reconstructive Medicine, Stanford University School of Medicine, Stanford University, Stanford, CA.
  • Gurtner G; From the Division of Plastic and Reconstructive Medicine, Stanford University School of Medicine, Stanford University, Stanford, CA.
  • Sen S; Department of Surgery, the University of Arizona College of Medicine, Tucson, AZ.
Ann Surg Open ; 5(1): e372, 2024 Mar.
Article en En | MEDLINE | ID: mdl-38883943
ABSTRACT
MINI-ABSTRACT In this study, we present the first-in-human use of topical deferoxamine (DFO) in the treatment of a beta-thalassemia wound. We elected to use DFO on a patient that suffered from a chronic nonhealing wound in the setting of beta-thalassemia. Despite approximately 55 weeks of marginal improvement in healing, this patient's wound healed completely after 21 weeks of treatment with DFO. We believe that DFO has the potential to accelerate healing in beta-thalassemia wounds through iron chelation.

Texto completo: 1 Base de datos: MEDLINE Idioma: En Revista: Ann Surg Open Año: 2024 Tipo del documento: Article

Texto completo: 1 Base de datos: MEDLINE Idioma: En Revista: Ann Surg Open Año: 2024 Tipo del documento: Article