Systemic Inflammation Differences in Brain-vs. Circulatory-Dead Donors: Impact on Lung Transplant Recipients.
Transpl Int
; 37: 12512, 2024.
Article
en En
| MEDLINE
| ID: mdl-38887494
ABSTRACT
Brain death triggers a systemic inflammatory response. Whether systemic inflammation is different in lung donors after brain- (DBD) or circulatory-death (DCD) is unknown, but this may potentially increase the incidence of primary graft dysfunction (PGD) after lung transplantation. We compared the plasma levels of interleukin (IL)-6, IL-8, IL-10 and TNF-α in BDB and DCD and their respective recipients, as well as their relationship with PGD and mortality after LT. A prospective, observational, multicenter, comparative, cohort-nested study that included 40 DBD and 40 DCD lung donors matched and their respective recipients. Relevant clinical information and blood samples were collected before/during lung retrieval in donors and before/during/after (24, 48 and 72 h) LT in recipients. Incidence of PGD and short-term mortality after LT was recorded. Plasma levels of all determined cytokines were numerically higher in DBD than in DCD donors and reached statistical significance for IL-6, IL-10 and IL-8. In recipients with PGD the donor's plasma levels of TNF-α were higher. The post-operative mortality rate was very low and similar in both groups. DBD is associated with higher systemic inflammation than DCD donors, and higher TNF-α plasma levels in donors are associated with a higher incidence of PGD.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Donantes de Tejidos
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Muerte Encefálica
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Trasplante de Pulmón
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Disfunción Primaria del Injerto
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Inflamación
Idioma:
En
Revista:
Transpl Int
/
Transplant international
/
Transplant. int
Asunto de la revista:
TRANSPLANTE
Año:
2024
Tipo del documento:
Article