Review of chemical models and applications in Geant4-DNA: Report from the ESA BioRad III Project.

Tran, Hoang Ngoc; Archer, Jay; Baldacchino, Gérard; Brown, Jeremy M C; Chappuis, Flore; Cirrone, Giuseppe Antonio Pablo; Desorgher, Laurent; Dominguez, Naoki; Fattori, Serena; Guatelli, Susanna; Ivantchenko, Vladimir; Méndez, José-Ramos; Nieminen, Petteri; Perrot, Yann; Sakata, Dousatsu; Santin, Giovanni; Shin, Wook-Geun; Villagrasa, Carmen; Zein, Sara; Incerti, Sebastien

Tran, Hoang Ngoc; Archer, Jay; Baldacchino, Gérard; Brown, Jeremy M C; Chappuis, Flore; Cirrone, Giuseppe Antonio Pablo; Desorgher, Laurent; Dominguez, Naoki; Fattori, Serena; Guatelli, Susanna; Ivantchenko, Vladimir; Méndez, José-Ramos; Nieminen, Petteri; Perrot, Yann; Sakata, Dousatsu; Santin, Giovanni; Shin, Wook-Geun; Villagrasa, Carmen; Zein, Sara; Incerti, Sebastien.

Afiliación

Tran HN; Univ. Bordeaux, CNRS, LP2I, UMR 5797, Gradignan, France.
Archer J; Centre For Medical and Radiation Physics, University of Wollongong, Wollongong, New South Wales, Australia.
Baldacchino G; Université Paris-Saclay, CEA, LIDYL, Gif-sur-Yvette, France.
Brown JMC; CY Cergy Paris Université, CEA, LIDYL, Gif-sur-Yvette, France.
Chappuis F; Optical Sciences Centre, Department of Physics and Astronomy, School of Science, Swinburne University of Technology, Melbourne, Australia.
Cirrone GAP; Institute of Radiation Physics (IRA), Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Desorgher L; Istituto Nazionale di Fisica Nucleare (INFN), Laboratori Nazionali del Sud (LNS), Catania, Italy.
Dominguez N; Centro Siciliano di Fisica Nucleare e Struttura della Materia, Catania, Italy.
Fattori S; Institute of Radiation Physics (IRA), Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Guatelli S; Department of Radiation Oncology, University of California San Francisco, San Francisco, California, USA.
Ivantchenko V; Istituto Nazionale di Fisica Nucleare (INFN), Laboratori Nazionali del Sud (LNS), Catania, Italy.
Méndez JR; Centre For Medical and Radiation Physics, University of Wollongong, Wollongong, New South Wales, Australia.
Nieminen P; CERN, Geneva, Switzerland.
Perrot Y; Department of Radiation Oncology, University of California San Francisco, San Francisco, California, USA.
Sakata D; European Space Agency, ESTEC, Noordwijk, The Netherlands.
Santin G; Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Fontenay-aux-Roses, France.
Shin WG; Centre For Medical and Radiation Physics, University of Wollongong, Wollongong, New South Wales, Australia.
Villagrasa C; Division of Health Sciences, Osaka University, Osaka, Japan.
Zein S; School of Physics, University of Bristol, Bristol, UK.
Incerti S; European Space Agency, ESTEC, Noordwijk, The Netherlands.

Med Phys ; 2024 Jun 18.

Article en En | MEDLINE | ID: mdl-38889367

ABSTRACT

ABSTRACT

A chemistry module has been implemented in Geant4-DNA since Geant4 version 10.1 to simulate the radiolysis of water after irradiation. It has been used in a number of applications, including the calculation of G-values and early DNA damage, allowing the comparison with experimental data. Since the first version, numerous modifications have been made to the module to improve the computational efficiency and extend the simulation to homogeneous kinetics in bulk solution. With these new developments, new applications have been proposed and released as Geant4 examples, showing how to use chemical processes and models. This work reviews the models implemented and application developments for modeling water radiolysis in Geant4-DNA as reported in the ESA BioRad III Project.

Palabras clave

Geant4DNA; radiation chemistry; water radiolysis

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