Low-dose decitabine plus venetoclax as post-transplant maintenance for high-risk myeloid malignancies.
EJHaem
; 5(3): 560-564, 2024 Jun.
Article
en En
| MEDLINE
| ID: mdl-38895080
ABSTRACT
Relapse remains a major cause of treatment failure following allogeneic stem cell transplantation (allo-SCT) for patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). We retrospectively investigated low-dose decitabine and venetoclax (DEC/VEN) as post-transplant maintenance in 26 older patients with AML and MDS. The cumulative incidence of day 100 gIII-IV acute graft versus host disease (GVHD) and 1-year moderate-severe chronic GVHD was 5% and 26%, respectively. One patient relapsed 14 m after transplant. The 1-year non-relapse mortality and survival were 11% and 84%, respectively. DEC/VEN is a safe and potentially effective strategy to reduce the risk of post-transplant relapse.
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MEDLINE
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EJHaem
Año:
2024
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Article