Deciphering extracellular vesicles protein cargo in pancreatic cancer.
Biochim Biophys Acta Rev Cancer
; 1879(5): 189142, 2024 Jun 22.
Article
en En
| MEDLINE
| ID: mdl-38914240
ABSTRACT
Pancreatic ductal adenocarcinoma (PDAC) presents a significant therapeutic challenge as it is frequently diagnosed at advanced inoperable stages. Therefore, the development of a reliable screening tool for PDAC is crucial for effective prevention and treatment. Extracellular vesicles (EVs), characterized by their cup-shaped lipid bilayer structure and ubiquitous release from various cell types, offer notable advantages as an emerging liquid biopsy technique that is rapid, minimally invasive, easily sampled, and cost-effective. While EVs play a substantial role in cancer progression, EV proteins serve as direct mediators of diverse cellular behaviors and have immense potential as biomarkers for PDAC diagnosis and prognostication. This review provides an overview of EV proteins regarding PDAC diagnosis and prognostic implications as well as disease progression.
Texto completo:
1
Base de datos:
MEDLINE
Idioma:
En
Revista:
Biochim Biophys Acta Rev Cancer
Año:
2024
Tipo del documento:
Article