[The Prognostic Value of Del(1p32) in Patients with Newly Diagnosed Multiple Myeloma].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
; 32(3): 768-773, 2024 Jun.
Article
en Zh
| MEDLINE
| ID: mdl-38926965
ABSTRACT
OBJECTIVE:
To analyze the prognostic value of del(1p32) in patients with newly diagnosed multiple myeloma (MM).METHODS:
The clinical data of 341 newly diagnosed MM attended in Jiangsu Province Hospital were retrospective analyzed. Clinical characteristic combined with genetic features, especially del(1p32), were analyzed for survival and prognostic of patients.RESULTS:
Among the 341 patients with newly diagnosed MM, 24(7.0%) patients were del(1p32) positive. The progression-free survival (PFS) and overall survival (OS) were significantly shorter in MM patients with del(1p32) than those without del(1p32) (PFS P < 0.001;OS P < 0.001). The COX proportional-hazards model showed that del (1p32) was an independent risk factor for PFS and OS of patients with MM. The patients with both 1q21 gain/amplification and del(1p32), as "double-hit chromosome 1", have worse prognosis than those with only 1q21 gain/amplification or only del(1p32) (PFS P < 0.001; OS P < 0.001).CONCLUSION:
Del(1p32) is an independent risk factor for PFS and OS of patients with MM. Del(1p32) detection should be widely used in the prognostic analysis for newly diagnosed MM patients.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Cromosomas Humanos Par 1
/
Mieloma Múltiple
Idioma:
Zh
Revista:
Zhongguo Shi Yan Xue Ye Xue Za Zhi
Asunto de la revista:
HEMATOLOGIA
Año:
2024
Tipo del documento:
Article