Aquaporins: Gatekeepers of Fluid Dynamics in Traumatic Brain Injury.
Int J Mol Sci
; 25(12)2024 Jun 14.
Article
en En
| MEDLINE
| ID: mdl-38928258
ABSTRACT
Aquaporins (AQPs), particularly AQP4, play a crucial role in regulating fluid dynamics in the brain, impacting the development and resolution of edema following traumatic brain injury (TBI). This review examines the alterations in AQP expression and localization post-injury, exploring their effects on brain edema and overall injury outcomes. We discuss the underlying molecular mechanisms regulating AQP expression, highlighting potential therapeutic strategies to modulate AQP function. These insights provide a comprehensive understanding of AQPs in TBI and suggest novel approaches for improving clinical outcomes through targeted interventions.
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Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Acuaporinas
/
Lesiones Traumáticas del Encéfalo
Idioma:
En
Revista:
Int J Mol Sci
Año:
2024
Tipo del documento:
Article