Association between telomere length and cognitive function among cognitively unimpaired individuals at risk of Alzheimer's disease.

Rodríguez-Fernández, Blanca; Sánchez-Benavides, Gonzalo; Genius, Patricia; Minguillon, Carolina; Fauria, Karine; De Vivo, Immaculata; Navarro, Arcadi; Molinuevo, Jose Luis; Gispert, Juan Domingo; Sala-Vila, Aleix; Vilor-Tejedor, Natalia; Crous-Bou, Marta

Rodríguez-Fernández, Blanca; Sánchez-Benavides, Gonzalo; Genius, Patricia; Minguillon, Carolina; Fauria, Karine; De Vivo, Immaculata; Navarro, Arcadi; Molinuevo, Jose Luis; Gispert, Juan Domingo; Sala-Vila, Aleix; Vilor-Tejedor, Natalia; Crous-Bou, Marta.

Afiliación

Rodríguez-Fernández B; Barcelonaßeta Brain Research Center (BBRC), Pasqual Maragall Foundation, C/ de Wellington, 30, Barcelona 08005, Spain; IMIM - Hospital del Mar Medical Research Institute, C/ del Dr. Aiguader, 88, 2nd floor, Campus Mar, Barcelona 08003, Spain; Centre for Genomic Regulation (CRG), The Barcelona Instit
Sánchez-Benavides G; Barcelonaßeta Brain Research Center (BBRC), Pasqual Maragall Foundation, C/ de Wellington, 30, Barcelona 08005, Spain; IMIM - Hospital del Mar Medical Research Institute, C/ del Dr. Aiguader, 88, 2nd floor, Campus Mar, Barcelona 08003, Spain; Centro de Investigación Biomédica en Red de Fragilidad y
Genius P; Barcelonaßeta Brain Research Center (BBRC), Pasqual Maragall Foundation, C/ de Wellington, 30, Barcelona 08005, Spain; IMIM - Hospital del Mar Medical Research Institute, C/ del Dr. Aiguader, 88, 2nd floor, Campus Mar, Barcelona 08003, Spain; Centre for Genomic Regulation (CRG), The Barcelona Instit
Minguillon C; Barcelonaßeta Brain Research Center (BBRC), Pasqual Maragall Foundation, C/ de Wellington, 30, Barcelona 08005, Spain; IMIM - Hospital del Mar Medical Research Institute, C/ del Dr. Aiguader, 88, 2nd floor, Campus Mar, Barcelona 08003, Spain; Centro de Investigación Biomédica en Red de Fragilidad y
Fauria K; Barcelonaßeta Brain Research Center (BBRC), Pasqual Maragall Foundation, C/ de Wellington, 30, Barcelona 08005, Spain; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBER-FES). Instituto de Salud Carlos III, C/ Monforte de Lemos 3-5. Pabellón 11, Planta 0, Madrid
De Vivo I; Department of Epidemiology, Harvard T.H. Chan School of Public Health. School of Public Health 2, 677 Huntington Ave, Boston, MA 02115, USA; Channing Division of Network Medicine, Harvard Medical School, Boston, MA 02115, USA.
Navarro A; Barcelonaßeta Brain Research Center (BBRC), Pasqual Maragall Foundation, C/ de Wellington, 30, Barcelona 08005, Spain; Centre for Genomic Regulation (CRG), The Barcelona Institute for Science and Technology, C/ del Dr. Aiguader, 88, Barcelona 08003, Spain; Institute of Evolutionary Biology (CSIC-UPF
Molinuevo JL; Barcelonaßeta Brain Research Center (BBRC), Pasqual Maragall Foundation, C/ de Wellington, 30, Barcelona 08005, Spain.
Gispert JD; Barcelonaßeta Brain Research Center (BBRC), Pasqual Maragall Foundation, C/ de Wellington, 30, Barcelona 08005, Spain; IMIM - Hospital del Mar Medical Research Institute, C/ del Dr. Aiguader, 88, 2nd floor, Campus Mar, Barcelona 08003, Spain; Centro de Investigación Biomédica en Red Bioingeniería, B
Sala-Vila A; Barcelonaßeta Brain Research Center (BBRC), Pasqual Maragall Foundation, C/ de Wellington, 30, Barcelona 08005, Spain; IMIM - Hospital del Mar Medical Research Institute, C/ del Dr. Aiguader, 88, 2nd floor, Campus Mar, Barcelona 08003, Spain.
Vilor-Tejedor N; Barcelonaßeta Brain Research Center (BBRC), Pasqual Maragall Foundation, C/ de Wellington, 30, Barcelona 08005, Spain; IMIM - Hospital del Mar Medical Research Institute, C/ del Dr. Aiguader, 88, 2nd floor, Campus Mar, Barcelona 08003, Spain; Centre for Genomic Regulation (CRG), The Barcelona Instit
Crous-Bou M; Barcelonaßeta Brain Research Center (BBRC), Pasqual Maragall Foundation, C/ de Wellington, 30, Barcelona 08005, Spain; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBER-FES). Instituto de Salud Carlos III, C/ Monforte de Lemos 3-5. Pabellón 11, Planta 0, Madrid

Neurobiol Aging ; 141: 140-150, 2024 Jun 01.

Article en En | MEDLINE | ID: mdl-38936230

ABSTRACT

ABSTRACT

INTRODUCTION:

Leukocyte telomere length (LTL) is an objective biomarker of biological aging, and it is proposed to play a crucial role in Alzheimer's disease (AD) risk. We aimed at evaluating the cross-sectional association between LTL and cognitive performance in middle-aged cognitively unimpaired individuals at increased risk of AD.

METHODS:

A total of 1520 participants from the ALFA cohort were included. Relative telomere length was measured in leukocytes through qPCR. LTL was residualized against age and sex, and associations with cognitive performance were assessed in short and long groups based on residualized LTL (rLTL). Interactions with sex and genetic risk of AD were tested.

RESULTS:

Non-linear associations were found between LTL and episodic memory (EM). Better EM was associated with longer rLTL among women in the short rLTL group.