Cerebral vasomotor reactivity in the acute phase and after 6 months in non-disabling stroke/TIA: A prospective cohort study.
J Stroke Cerebrovasc Dis
; 33(9): 107841, 2024 Sep.
Article
en En
| MEDLINE
| ID: mdl-38945417
ABSTRACT
BACKGROUND AND AIM:
Cerebral Vasomotor Reactivity (VMR) is a property of cerebral hemodynamics that protects from cerebrovascular disease. We aimed to explore the VMR longitudinal changes in patients with acute non-disabling stroke/Transient Ischemic Attack (TIA) to understand its implication in stroke ethiopatogenesis.METHODS:
VMR by Transcranial Doppler Breath Holding test was performed at 48-72 h from stroke onset (T1) and after 6 months (T2) on MCA of the non-affected hemisphere and PCA of the affected hemisphere.RESULTS:
We consecutively enrolled 124 patients with a median age of 66.0 (IQR 54.75-74.25) years with a median NIHSS 2 (IQR 1-3). Both MCA (1.38 %/s SD 0.58) and PCA (1.35 %/s SD 0.75) BHI at T1 did not differ among different stroke subtypes (p=0.067 and p=0.350; N=124). MCA and PCA BHI decreased from T1 to T2 (respectively 1.39 %/s SD 0.56 vs 1.18%/s SD 0.44 and 1.30 %/s SD 0.69 vs 1.20 %/s SD 0.51; N=109) regardless of ethiopatogenesis (respectively p<0.0001 and p=0.111).CONCLUSION:
The VMR is higher in acute phase than at 6 months in patients with non-disabling stroke/TIA, regardless of etiopathogenesis. The higher VMR in acute phase could be sustained by an increased Cerebral Blood Flow due to collateral circulation activation supporting the ischemic zone.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Ataque Isquémico Transitorio
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Circulación Cerebrovascular
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Ultrasonografía Doppler Transcraneal
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Contencion de la Respiración
Idioma:
En
Revista:
J Stroke Cerebrovasc Dis
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J. stroke cerebrovasc. dis
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Journal of stroke and cerebrovascular diseases
Asunto de la revista:
ANGIOLOGIA
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CEREBRO
Año:
2024
Tipo del documento:
Article