Effect of Oleuropein on Anti-Obesity and Uncoupling Protein 1 Level in Brown Adipose Tissue in Mild Treadmill Walking Rats with Diet-Induced Obesity.
J Nutr Sci Vitaminol (Tokyo)
; 70(3): 193-202, 2024.
Article
en En
| MEDLINE
| ID: mdl-38945884
ABSTRACT
Oleuropein aglycone (OA), which is the absorbed form of oleuropein, is a major phenolic compound in extra virgin olive oil. We analyzed the anti-obesity effect of OA intake combined with mild treadmill walking (MTW, 4 m/min for 20 min/d, 5-6 d/wk, without electric shocks and slope) in rats under a high-fat diet (HF). Four-week-old male Sprague-Dawley rats (n=28) were equally divided into four groups control (HF), 0.08% oleuropein-supplemented HF (HFO), HF with MTW (HF+W), and HFO with MTW (HFO+W) groups. After 28 d, the inguinal subcutaneous fat content and weight gain were significantly lower in the HFO+W group than in the control group. The HFO+W group also had significantly higher levels of urinary noradrenaline secretion, interscapular brown adipose tissue, uncoupling protein 1, brain transient receptor potential ankyrin subtype 1 (TRPA1), vanilloid subtype 1 (TRPV1), and brain-derived neurotrophic factor (BDNF) than the control group. Especially, the HFO+W group showed a synergistic effect on noradrenaline secretion. Therefore, OA combined with MTW may accelerate the enhancement of UCP1 and BDNF levels in rats with HF-induced obesity by increasing noradrenaline secretion after TRPA1 and TRPV1 activation.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Tejido Adiposo Pardo
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Norepinefrina
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Ratas Sprague-Dawley
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Factor Neurotrófico Derivado del Encéfalo
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Iridoides
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Glucósidos Iridoides
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Dieta Alta en Grasa
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Proteína Desacopladora 1
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Canal Catiónico TRPA1
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Obesidad
Idioma:
En
Revista:
J Nutr Sci Vitaminol (Tokyo)
Año:
2024
Tipo del documento:
Article