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Structural Diversification of Pyrazinone Metabolites via Spontaneous Oxa-Michael Addition in Staphylococcus xylosus.
Lee, Ju Ryeong; Hwang, Su Jung; Choi, Yukyung; Kim, Jonghwan; Lee, Gyu Sung; Lee, Bum Soo; Kim, Ki Hyun; Kang, Kyo Bin; Lee, Hyo-Jong; Kim, Chung Sub.
Afiliación
  • Lee JR; Department of Biopharmaceutical Convergence, Sungkyunkwan University, Suwon 16419, Republic of Korea.
  • Hwang SJ; School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.
  • Choi Y; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Sookmyung Women's University, Seoul 04310, Republic of Korea.
  • Kim J; Department of Biopharmaceutical Convergence, Sungkyunkwan University, Suwon 16419, Republic of Korea.
  • Lee GS; Department of Biopharmaceutical Convergence, Sungkyunkwan University, Suwon 16419, Republic of Korea.
  • Lee BS; School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.
  • Kim KH; School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.
  • Kang KB; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Sookmyung Women's University, Seoul 04310, Republic of Korea.
  • Lee HJ; School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.
  • Kim CS; Department of Biopharmaceutical Convergence, Sungkyunkwan University, Suwon 16419, Republic of Korea.
J Nat Prod ; 87(7): 1881-1887, 2024 Jul 26.
Article en En | MEDLINE | ID: mdl-38950087
ABSTRACT
A family of pyrazinone metabolites (1-11) were characterized from Staphylococcus xylosus ATCC 29971. Six of them were hydroxylated or methoxylated, which were proposed to be produced by the rare noncatalytic oxa-Michael addition reaction with a water or methanol molecule. It was confirmed that isopropyl alcohol can also be the Michael donor of the reaction. 1-7 and the synthetic precursor 2a showed significant inhibition of breast cancer cell migration.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Pirazinas / Staphylococcus Idioma: En Revista: J Nat Prod Año: 2024 Tipo del documento: Article
Texto completo
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Pirazinas / Staphylococcus Idioma: En Revista: J Nat Prod Año: 2024 Tipo del documento: Article