Ectonucleotidase Activity in Smooth Muscle Tissues of Rats with a Valproate Model of Autism.
Bull Exp Biol Med
; 177(1): 47-50, 2024 May.
Article
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| MEDLINE
| ID: mdl-38955852
ABSTRACT
Ectonucleotidases play an important role in regulating the level of extracellular nucleotides and nucleosides and are an important part of the regulation of the effects of adenosine and ATP on adenosine and P2 receptors, respectively. We have previously established the ambiguous effect of P2 receptor agonists on the contractile activity of smooth muscle tissue in rats with the valproate model of autism. In this work, HPLC was used to evaluate the activity of ectonucleotidases in the smooth muscle tissues of the internal organs of rats with a valproate model of autism. The activity of ectonucleotidases was significantly higher in the smooth muscle tissues of the duodenum, vas deferens, and bladder, but lower in the ileum and uterus. The results obtained make it possible to compare the activity of ectonucleotidases identified here with changes in P2 receptor-mediated contractility of smooth muscle tissues revealed in our previous experiments.
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MEDLINE
Asunto principal:
Trastorno Autístico
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Conducto Deferente
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Vejiga Urinaria
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Ácido Valproico
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Contracción Muscular
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Músculo Liso
Idioma:
En
Revista:
Bull Exp Biol Med
Año:
2024
Tipo del documento:
Article