Mechanistic insights into mesenchymal-amoeboid transition as an intelligent cellular adaptation in cancer metastasis and resistance.
Biochim Biophys Acta Mol Basis Dis
; 1870(7): 167332, 2024 10.
Article
en En
| MEDLINE
| ID: mdl-38960056
ABSTRACT
Malignant cell plasticity is an important hallmark of tumor biology and crucial for metastasis and resistance. Cell plasticity lets cancer cells adapt to and escape the therapeutic strategies, which is the leading cause of cancer patient mortality. Epithelial cells acquire mobility via epithelial-mesenchymal transition (EMT), whereas mesenchymal cells enhance their migratory ability and clonogenic potential by acquiring amoeboid characteristics through mesenchymal-amoeboid transition (MAT). Tumor formation, progression, and metastasis depend on the tumor microenvironment (TME), a complex ecosystem within and around a tumor. Through increased migration and metastasis of cancer cells, the TME also contributes to malignancy. This review underscores the distinction between invasion pattern morphological manifestations and the diverse structures found within the TME. Furthermore, the mechanisms by which amoeboid-associated characteristics promote resistance and metastasis and how these mechanisms may represent therapeutic opportunities are discussed.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Transición Epitelial-Mesenquimal
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Microambiente Tumoral
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Metástasis de la Neoplasia
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Neoplasias
Idioma:
En
Revista:
Biochim Biophys Acta Mol Basis Dis
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Biochim. biophys. acta, Mol. basis dis
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Biochimica et biophysica acta. Molecular basis of disease
Año:
2024
Tipo del documento:
Article