[Optical coherence tomography in the diagnosis of multiple sclerosis]. / Opticheskaya kogerentnaya tomografiya v diagnostike rasseyannogo skleroza.
Vestn Oftalmol
; 140(3): 59-68, 2024.
Article
en Ru
| MEDLINE
| ID: mdl-38962980
ABSTRACT
Multiple sclerosis (MS) is a chronic autoimmune-inflammatory and neurodegenerative disease. PURPOSE:
This study explores the main structural changes in patients with MS and their relationships with the activity and type of disease course. MATERIAL ANDMETHODS:
This prospective study included 159 patients (318 eyes) with an established diagnosis of MS group (44 eyes; 13.84%) - relapsing-remitting type MS (RRMS) lasting up to 1 year without a history of optic neuritis (ON); group 2 (30 eyes; 9.43%) - RRMS up to 1 year with ON; group 3 (56 eyes; 17.61%) - RRMS lasting from 1 to 10 years without ON; group 4 (38 eyes; 11.95%) - RRMS from 1 to 10 years with ON; group 5 (49 eyes; 15.41%) - RRMS >10 years without ON; group 6 (37 eyes; 11.63%) - RRMS >10 years with ON; group 7 (34 eyes; 10.69%) - secondary progressive multiple sclerosis (SPMS) without ON; group 8 (30 eyes; 9.43%) - SPMS with ON. Patients underwent standard ophthalmological examinations, including optical coherence tomography.RESULTS:
A decrease in structural parameters was diagnosed, progressing with the duration of the disease and the presence of ON the minimum values of mGCL+IPL (65.83±9.14 µm) and mSNFL (76.37±14.77 µm) were detected in the group with SPMS with ON. High inverse correlations of EDSS with mGCL+IPL and mRNFL were demonstrated, with maximum in the group with the longest duration of MS without ON (-0.48 and -0.52 (p=0.01), respectively).CONCLUSION:
Changes in the thickness of the structural parameters of the retina, measured by OCT, can be considered as a predictor of the course of MS.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Neuritis Óptica
/
Tomografía de Coherencia Óptica
/
Esclerosis Múltiple
Idioma:
Ru
Revista:
Vestn Oftalmol
Año:
2024
Tipo del documento:
Article