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Discovery of sesquiterpene lactones with anti-inflammatory effect from Youngia japonica.
Ye, Xian-Sheng; Lin, Kuan; Leng, Chang-Long; Gui, Yu-Ran; Zhu, Shu-Xiu; Liu, Hui-Ying; Xia, Yi-Yuan; Sun, Bin-Lian; Liu, Wei; Shu, Xi-Ji.
Afiliación
  • Ye XS; Hubei Key Laboratory of Cognitive and Affective Disorders, Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan 430056, China.
  • Lin K; Hubei Key Laboratory of Cognitive and Affective Disorders, Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan 430056, China.
  • Leng CL; Hubei Key Laboratory of Cognitive and Affective Disorders, Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan 430056, China.
  • Gui YR; Hubei Key Laboratory of Cognitive and Affective Disorders, Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan 430056, China.
  • Zhu SX; Department of Traditional Chinese Medicine, School of Medicine, Jianghan University, Wuhan 430056, China.
  • Liu HY; The Institute of Translational Medicine, the Second Affiliated Hospital of Nanchang University, Nanchang 330000, China.
  • Xia YY; Hubei Key Laboratory of Cognitive and Affective Disorders, Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan 430056, China.
  • Sun BL; Hubei Key Laboratory of Cognitive and Affective Disorders, Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan 430056, China.
  • Liu W; Hubei Key Laboratory of Cognitive and Affective Disorders, Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan 430056, China.
  • Shu XJ; Hubei Key Laboratory of Cognitive and Affective Disorders, Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan 430056, China.
J Asian Nat Prod Res ; : 1-8, 2024 Jul 04.
Article en En | MEDLINE | ID: mdl-38963349
ABSTRACT
The preliminary study revealed that the ethyl acetate eluate of Youngia japonica (YJ-E) could inhibit the expression of key proteins of p-p65, p-IκBα, p-IKKα/ß, and p-AKT in LPS stimulated BV2 cell. Further phytochemical study led to the isolation of eight compounds from YJ-E, including one new sesquiterpene lactone. Their structures were elucidated by several spectroscopic data, and comparing the NMR data of known compound. In addition, all of the isolates were evaluated for the anti-inflammatory effect. As a result, compounds 3 and 4 distinctly attenuated the expressions of p-IκBα, p-p65, and p-AKT in LPS stimulated BV2 cell, respectively.
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Texto completo: 1 Base de datos: MEDLINE Idioma: En Revista: J Asian Nat Prod Res Asunto de la revista: BOTANICA / QUIMICA Año: 2024 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Idioma: En Revista: J Asian Nat Prod Res Asunto de la revista: BOTANICA / QUIMICA Año: 2024 Tipo del documento: Article