Pore-Forming VDAC Proteins of the Outer Mitochondrial Membrane: Regulation and Pathophysiological Role.
Biochemistry (Mosc)
; 89(6): 1061-1078, 2024 Jun.
Article
en En
| MEDLINE
| ID: mdl-38981701
ABSTRACT
Voltage-dependent anion channels (VDAC1-3) of the outer mitochondrial membrane are a family of pore-forming ß-barrel proteins that carry out controlled "filtration" of small molecules and ions between the cytoplasm and mitochondria. Due to the conformational transitions between the closed and open states and interaction with cytoplasmic and mitochondrial proteins, VDACs not only regulate the mitochondrial membrane permeability for major metabolites and ions, but also participate in the control of essential intracellular processes and pathological conditions. This review discusses novel data on the molecular structure, regulatory mechanisms, and pathophysiological role of VDAC proteins, as well as future directions in this area of research.
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Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Membranas Mitocondriales
/
Canales Aniónicos Dependientes del Voltaje
Idioma:
En
Revista:
Biochemistry (Mosc)
Año:
2024
Tipo del documento:
Article