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Iron-Catalyzed Sulfonylmethylation of Imidazo[1,2-α]pyridines with N,N-Dimethylacetamide and Sodium Sulfinates.
Sun, Shengnan; Ye, Hexia; Liu, Haibo; Li, Junchen; Bi, Xiaojing.
Afiliación
  • Sun S; State Key Laboratory of NBC Protection for Civilian, Beijing 102205, China.
  • Ye H; State Key Laboratory of NBC Protection for Civilian, Beijing 102205, China.
  • Liu H; State Key Laboratory of NBC Protection for Civilian, Beijing 102205, China.
  • Li J; State Key Laboratory of NBC Protection for Civilian, Beijing 102205, China.
  • Bi X; State Key Laboratory of NBC Protection for Civilian, Beijing 102205, China.
Molecules ; 29(13)2024 Jul 05.
Article en En | MEDLINE | ID: mdl-38999150
ABSTRACT
Functionalized imidazo[1,2-α]pyridines are important scaffolds in pharmaceuticals. Herein, we present an efficient 3-sulfonylmethylation protocol for imidazo[1,2-α]pyridines by sodium sulfinates in DMA and H2O (21) via an FeCl3-catalyzed three-component coupling reaction. Various sulfonylmethyl imidazo[1,2-α]pyridines were thus afforded in high yields with excellent functional group tolerance. A plausible oxidation-addition mechanism was proposed.
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Texto completo: 1 Base de datos: MEDLINE Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2024 Tipo del documento: Article

Texto completo: 1 Base de datos: MEDLINE Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2024 Tipo del documento: Article